Human cell culture volume i cancer cell lines part 1 human cell culture volume 1 the titles published in this series are listed at the end of this volume human cell culture volume i cancer cell lines part 1 edited by john rw masters series on human cell culture are devoted to these cancer cell lines. Lung cancer cell lines with varying degrees of genetic complexity including mutations in egfr ras pik3 and tp53. In a later targeted study 12 of 30 lung cancer cell lines were found to have different egfr mutations within the same cultures these studies indicate that the biologic mechanisms underlying heterogeneity within primary tumors may be operational in cell line models and that cell lines can be used to study heterogeneous responses to therapy. Methods mol biol 201173113 26 doi 101007 978 1 61779 080 5 2 principles of cancer cell culture cree ia1 but large numbers of well characterised cell lines are available from libraries maintained to a very high standard allowing the researcher to commence experiments rapidly and economically attention to safety and disposal is . Multiple initial culture conditions enhance the establishment of cell lines from primary ovarian cancer specimens palsson b o eds human cell culture volume ii cancer cell lines part 2 london kluwer 1999 google scholar
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